from cffi import FFI import numpy as np s = ''' typedef struct { int a; int b; float c; double d; } mystruct; ''' ffi = FFI() ffi.cdef(s) m_arr = ffi.new("mystruct[2]") #create array and fill with dummy data for k in range(2): m = m_arr[k] m.a = k m.b = k + 1 m.c = k + 2.0 m.d = k + 3.0 print(m_arr) # dtype for structured array in Numpy dt = np.dtype({'names': ('a', 'b', 'c', 'd'), 'formats': ('i4', 'i4', 'f4', 'f8'), 'offset': (ffi.offsetof('mystruct', 'a'), ffi.offsetof('mystruct', 'b'), ffi.offsetof('mystruct', 'c'), ffi.offsetof('mystruct', 'd'), ) }, align=True) # member size, 20 bytes print('size, manually', 4 + 4 + 4 + 8) # total size of struct, 24 bytes print('sizeof', ffi.sizeof(m_arr[0])) #reason is member padding in structs buf = ffi.buffer(m_arr) print(buf) x = np.frombuffer(buf, dtype=dt) print(x)